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If it is the first time I would recommend a brief overview and bar hopping the first day/night or so to get a feel for the places and the scene. Then you can spend time at the bars/areas you liked.
E.g. Make a tour of Nana Plaza, Soi Cowboy, Patpong and Soi 33 bars. I did that my first time in BKK except for the Soi 33 I still havent visit but I wish to see next time I go to BKK.
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